White Peony Extract powder

Product Name:White Peony Extract powder

Other Name:Chinese White Blossom Extract Powder

Botanical Source:Radix Paeoniae Alba

Ingredients: Total glucosides of Paeonia (TGP): Paeoniflorin, Oxypaeoniflorin, Albiflorin, Benzoylpaeoniflorin

Specifications:Paeoniflorin 10%~40% (HPLC), 1.5% Albasides, 80% Glycosides

CAS No.:23180-57-6

Colour: Yellowish-brown powder with characteristic odor and taste

GMO Status:GMO Free

Packing: in 25kgs fiber drums

Storage:Keep container unopened in cool, dry place,Keep away from strong light

Shelf Life:24 months from date of production

White Peony Extract refers to the extraction of active ingredients from white peony by scientific means according to a unique technology. According to the analysis of scholars, the active ingredients of white peony extract for the human body are as follows Chart. Four of the most important are Paeoniflorin, Oxypaeoniflorin, Albiflorin, and Benzoylpaeoniflorin.

White peony extract is extracted from the dried root of Paeonia lactiflora Pall., a plant of the Ranunculaceae family. Its main component is paeoniflorin, which can be widely used not only in the medical field but also in the cosmetics industry. White peony extract is a highly effective PDE4 activity inhibitor. By inhibiting PDE4 activity, it can make the cAMP of various inflammatory and immune cells (such as neutrophils, macrophages, T lymphocytes and eosinophils, etc.) reach a concentration sufficient to inhibit the activation of inflammatory cells and exert an anti-inflammatory effect. It also has analgesic, antispasmodic, anti-ulcer, vasodilator, increased organ blood flow, antibacterial, liver-protecting, detoxifying, anti-mutagenic, and anti-tumor effects.

1,2,3,6-tetragalloyl glucose, 1,2,3,4,6-pentagalloyl glucose and the corresponding hexagalloyl glucose and heptagalloyl glucose were isolated from the tannin of white peony root. It also contains dextrorotatory catechin and volatile oil. The volatile oil mainly contains benzoic acid, peony phenol and other alcohols and phenols. 1. Paeoniflorin: molecular formula C23H28O11, molecular weight 480.45. Hygroscopic amorphous powder, [α]D16-12.8° (C=4.6, methanol), tetraacetate is colorless needle crystals, mp.196℃. 2. Paeonol: Synonyms are paeonol, peony alcohol, paeonal, and peonol. Molecular formula C9H10O3, molecular weight 166.7. Colorless needle-shaped crystals (ethanol), mp.50℃, slightly soluble in water, can volatilize with water vapor, soluble in ethanol, ether, acetone, chloroform, benzene and carbon disulfide. 3. Others: Contains a small amount of oxypaeoniflorin, albiforin, benzoylpaeoniflorin, lactiflorin, a new monoterpene paeoniflorigenone with neuromuscular blocking effect on mice, 1,2,3,4,6-Pentagalloylglucose with antiviral effect, gallotannin, d-catechin, gallic acid, ethyl gallate, tannin, β-sitosterol, sugar, starch, mucus, etc.

Functions:

1. Anti-inflammatory, antibacterial and antiviral effects. White peony extract has a significant inhibitory effect on egg white acute inflammatory edema in rats and inhibits the proliferation of cotton ball granuloma. Total glycosides of paeony have anti-inflammatory and body-dependent immunomodulatory effects on rats with adjuvant arthritis. White peony preparations have certain inhibitory effects on Staphylococcus aureus, hemolytic Streptococcus, pneumococcus, Shigella dysenteriae, Typhoid bacillus, Vibrio cholerae, Escherichia coli and Pseudomonas aeruginosa. In addition, 1:40 peony decoction can inhibit Jingke 68-1 virus and herpes virus.

2. Hepatoprotective effect. White peony extract has a significant antagonistic effect on liver damage and SGPT increase caused by D-galactosamine. It can reduce SGPT and restore liver cell lesions and necrosis to normal. The ethanol extract of white peony root can reduce the increase in the total activity of lactate dehydrogenase and isoenzymes in rats with acute liver injury caused by aflatoxin. Total glycosides of paeony can inhibit the increase in SGPT and lactate dehydrogenase in mice caused by carbon tetrachloride, and have an antagonistic effect on eosinophilic degeneration and necrosis of liver tissue.

3. Antioxidant effect: White peony root extract TGP has antioxidant and cell membrane stabilizing effects, and may have a scavenging effect on free radicals.

4. Cardiovascular system effects White peony extract can expand the coronary blood vessels of the isolated heart, resist acute myocardial ischemia in rats caused by pituitaryin, and reduce peripheral vascular resistance and increase blood flow when injected into the artery. Paeoniflorin also has a dilating effect on coronary blood vessels and peripheral blood vessels, and causes a decrease in blood pressure. Studies have shown that paeoniflorin, an extract of white peony root, has an inhibitory effect on ADP-induced platelet aggregation in rats in vitro.

5. Gastrointestinal effects White peony extract has an inhibitory effect on the spontaneous contraction of intestinal hyperexcitability and the contraction caused by barium chloride, but has no effect on the contraction caused by acetylcholine. The water-extracted mixture of licorice and white peony root (0.21g) has a significant inhibitory effect on the movement of intestinal smooth muscle in rabbits in vivo. The combined effect of the two is better than that of either alone, and the frequency-reducing effect is stronger than the amplitude-reducing effect. The reduction in rabbit intestinal contraction frequency 20 to 25 minutes after administration was 64.71% and 70.59% of that in the normal control group, respectively, and was stronger than that of atropine (0.25 mg) in the positive control group. Paeoniflorin has inhibitory effects on isolated intestinal tubes and in vivo gastric motility in guinea pigs and rats, as well as rat uterine smooth muscle, and can antagonize contractions caused by oxytocin. It has a synergistic effect with Chemicalbook alcohol extract FM100 of licorice. Paeoniflorin has a significant inhibitory effect on gastrointestinal ulcers in rats induced by stressful stimuli.

6. Sedative, analgesic, and anticonvulsant effects. White peony injection and paeoniflorin both have sedative and analgesic effects. Injecting a small amount of paeoniflorin into the brain ventricles of animals can induce an obvious sleep state. Intraperitoneal injection of 1g/kg of paeoniflorin from white peony root extract in mice can reduce the animals' spontaneous activities, prolong the sleep time of pentobarbital, inhibit the writhing reaction of mice caused by intraperitoneal injection of acetic acid, and resist pentylenetetrazole. Caused convulsions. Total glycosides of paeony have significant analgesic effects and can enhance the analgesic effects of morphine and clonidine. Naloxone does not affect the analgesic effect of total glycosides of paeony, suggesting that its analgesic principle is not to stimulate opioid receptors. Peony extract can inhibit convulsions caused by strychnine. Paeoniflorin has no effect on isolated skeletal muscle, so it is inferred that its anticonvulsant effect is central.

7. Effect on the blood system: Paeony alcohol extract can inhibit platelet aggregation in rabbits induced by ADP, collagen, and arachidonic acid in vitro.

8. Effect on the immune system. White peony root can promote the production of spleen cell antibodies and specifically enhance the humoral response of mice to sheep red blood cells. White peony decoction can antagonize the inhibitory effect of cyclophosphamide on peripheral blood T lymphocytes in mice, restore them to normal levels, and restore the low cellular immune function to normal. Total glycosides of paeony can promote the proliferation of splenic lymphocytes in mice induced by concanavalin, promote the production of α-interferon in human cord blood leukocytes induced by Newcastle chicken plague virus, and have a bidirectional effect on the production of interleukin-2 in rat splenocytes induced by concanavalin. regulating effect.

9. Strengthening effect: White peony alcohol extract can prolong the swimming time of mice and the hypoxic survival time of mice, and has a certain strengthening effect.

10. Anti-mutagenic and anti-tumor effects White peony extract can interfere with the enzyme activity of the S9 mixture, and can inactivate the metabolites of benzopyrene and inhibit its mutagenic effect.

11. Other effects (1) Antipyretic effect: Paeoniflorin has an antipyretic effect on mice with artificial fever and can reduce the normal body temperature of mice. (2) Memory-enhancing effect: Total glycosides of paeony can improve the poor learning and memory acquisition in mice caused by scopolamine. (3) Anti-hypoxic effect: Total glycosides of white paeony can prolong the survival time of mice under normal pressure and hypoxia, reduce the overall oxygen consumption of mice, and reduce the mortality of mice due to potassium cyanide poisoning and hypoxia.