S-adenosyl-L-methionine disulfate tosylate

Product Name:S-adenosyl-L-methionine disulfate tosylate

Other Name:Ademetionine disulfate tosylate; AdeMethionine Disulfate Tosylate; SAM-TAdemetionine disulfate tosylate; Ademetionine Disulfate Tosylate(SAMe)

CAS No:97540-22-2

Assay:  98%Min

Colour: White fine Powder

GMO Status:GMO Free

Packing: in 25kgs fiber drums

Storage:Keep container unopened in cool, dry place,Keep away from strong light

Shelf Life:24 months from date of production

Adenosyl-L-methionine disulfate tosylate (SAMe) is a dietary supplement that is used to treat depression and liver disease. It is also a metabolite of the amino acid methionine, which is formed by the enzyme S-adenosylmethionine synthase.

S-Adenosyl-L-methionine is simply called SAMe or SAM-e in America, and also aliased as AdoMet or SAM. The names S-adenosyl methionine and S-adenosylmethionine also mean same substance S-Adenosyl-L-methionine. It is present naturally in the human body and plays an essential role in kinds of reactions in the body.

SAMe donates methyl group in kinds of biosynthesis of proteins, neurotransmitters, nucleic and nucleic acids. This happens in many enzymatic transmethylation reactions.

Adenosylmethionine (SAMe) is a naturally-occurring compound found in almost every tissue and fluid in the body. It is involved in many important processes. SAMe plays a role in the immune system, maintains cell membranes, and helps produce and break down brain chemicals, such as serotonin, melatonin, and dopamine.

Taking SAMe by mouth seems to work about as well as ibuprofen and other similar drugs for reducing symptoms of osteoarthritis. But most people need to take SAMe for about a month before they feel better.

People generally use SAMe to treat depression, osteoarthritis and liver disease. However, SAMe can also interact with antidepressant medications.

It may detoxify harmful substances in the body. These include heavy metals. It may also prevent liver damage from acetaminophen poisoning and help prevent fat deposits in your liver. It may also help ease fatigue and reduce the risk of early balding.

In eukaryotic cells, SAM serves as a regulator of a variety of processes including DNA, tRNA, and rRNA methylation; immune response; amino acid metabolism; transsulfuration; and more. In plants, SAM is crucial to the biosynthesis of ethylene, an important plant hormone and signaling molecule.

T-Adenosylmethionine (SAMe) is a naturally-occurring compound found in almost every tissue and fluid in the body. It is involved in many important processes. SAMe plays a role in the immune system, maintains cell membranes, and helps produce and break down brain chemicals, such as serotonin, melatonin, and dopamine.

Function

Transmethylation 

SAMe is the most important methyl donor in the body, and at least 35 different methyl transferase reactions have been found to require SA M as a methyl donor. SAM is used for the biosynthesis of many nitrogenous substances, such as creatine, choline, epinephrine, pinecone, carnitine, and myosin.

Transaminopropyl action

SAMe participates in the synthesis of bioamines by transaminopropyl. Spermidine and spermidine are important polyamines in eukaryotes. After two deshutters, SAM generates 5 '-methiodophyl (MTA), and then transfers aminopropyl to puttriamine or spermidine to produce the corresponding spermidine and spermidine.

Trans sulfur action

SAMe is an active precursor of sulfur-containing compounds such as cysteine and glutathione (GSH). SAM produces homocysteine through conversion of sulfur, followed by catabolic generation of cysteine, which is then regenerated into glutathione (GS H).

Application 

Treatment of viral hepatitis

As an exogenous adenosylmethionine, S-adenosylmethionine can supplement the endogenous adenosylmethionine in children with liver damage, effectively reduce the enterohepatic circulation of cholic acid, protect damaged liver cells, and promote the regression of jaundice. In addition, S- adenosine methionine is also effective in the treatment of infantile liver syndrome.

Treatment of alcoholic liver disease 

Studies have been found that s-adenosine in the treatment of patients with alcoholic hepatitis can significantly improve their poor appetite, nausea, vomiting, fatigue, abdominal distension, skin itching and other symptoms, at the same time in reducing serum bilirubin and improve liver function has a good effect, and safe use, no obvious adverse reactions were found in the treatment process. But the treatment of alcoholic hepatitis, abstaining from alcohol is extremely important, is also its most basic treatment method.

Treatment of Intrahepatic cholestasis of pregnancy

S-adenosyl-L-methionine powder can significantly improve the biochemical indicators of cholestasis and prurituria symptoms, so it is considered that S-adenosine is one of the safe and effective drugs for the treatment of intrahepatic cholestasis.